Wednesday, 03. of September 2014
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CoaguChek® XS System

The CoaguChek systems have been widely accepted for home and professional use since the first model was introduced in 1994, then followed in 2000 by the CoaguChek S system. In the beginning of 2006 the latest model, the CoaguChek XS system, is launched.
 
The CoaguChek® XS system is a device which measures PT/INR values in capillary whole blood.
Therefore one drop of 10 microliters is needed. The fast (1 minute to get a result), compact, easy-to-use monitor is ideal for use at home or in a doctor’s practice. All of the information needed to calibrate the monitor is contained on a code chip which does away with the usual but cumbersome need for manual calibration, pipetting and preparation of reagents.
 
Through several innovative features, e.g. smaller size and weight, side and top blood dosing options, strips which can be stored at room temperature, etc. and thanks to various safety features (e.g. onboard quality control on each measured strip), the CoaguChek XS system will help to provide easier access to Coagulation Self-Testing.  
 
CoaguChek XS system from Roche Diagnostics provides patients with more independence and increases their quality of life. This is one of the reasons why the various CoaguChek systems are used by over 180,000 people in many countries. (2006)

Monitoring 

More and more persons require oral anticoagulation as a result of various medical conditions. Experts put the figure globally at 6 million in 2005; in Europe the number is approximately 2 million, and over 10 millions worldwide are foreseen by year 2010. 
For this staggering number of patient’s anticoagulation is an important and necessary life-long commitment. The efficacy of their treatment hinges quite decisively on the adjustment of coagulation to a steady figure within their therapeutic corridor. This can only be achieved through a regime of regular monitoring of values.  

Why regular Anticoagulation Monitoring is important

Oral anticoagulants have a narrow therapeutic range and the response to a standard dose varies widely both between patients and within patients over time. Changes in patient health, lifestyle or diet and other drugs can alter the effectiveness of the medication.
Potential interferences with coumarins requiring anticoagulation monitoring

  •  Diet: Foods high in vitamin K such as sprouts, cabbage, etc.  
  •  Alcohol  
  •  Drugs: Some painkillers, some antibiotics  
  •  Stress  
  • Ilnesses: E.g. diarrhea  

These potential interferences, added to the fact that each individual has a different reaction to vitamin K antagonists, require that prothrombin time (PT)/International normalised ratio (INR) is monitored regularly.
The time within the therapeutic range is considered as a key indicator of the patient's safety in terms of less potential complications such as haemorrhage or thrombosis. Oral anticoagulant dosages are then adjusted by the healthcare professional according to the results of the PT/INR test.

Roche Diagnostics (2007)